Evaluation of the Effects of Donepezil, Memantine and alpha-lipoic Acid Combined Administration in Amnesia Rats on Impaired Cognitive Functions in Terms of Behavioural, Apoptotic, Cholinergic and Glutamatergic Systems

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Aykac A., ÖZBEYLİ D., Pekol G., Sehirli A. O.

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, cilt.11, sa.4, ss.733-741, 2021 (ESCI)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 11 Sayı: 4
• Basım Tarihi: 2021
• Doi Numarası: 10.33808/clinexphealthsci.856459
• Dergi Adı: CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
• Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
• Sayfa Sayıları: ss.733-741
• Anahtar Kelimeler: Alpha-lipoic acid, amnesia, apoptosis, scopolamine, Y-maze, INDUCED MEMORY IMPAIRMENT, NEUROTROPHIC FACTOR, MUSCARINIC RECEPTORS, OXIDATIVE STRESS, SUBTYPES, MODEL, INFLAMMATION, ANTIOXIDANT, HIPPOCAMPUS, MECHANISMS
• Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
• Marmara Üniversitesi Adresli: Evet

Özet

Objective: The aim of the study was to evaluate the possible protective effect of donepezil, memantine and alpha-lipoic acid (alpha-LA) combined therapy in the scopolamine-induced amnesia rat model.