Evaluation of the Effects of Donepezil, Memantine and alpha-lipoic Acid Combined Administration in Amnesia Rats on Impaired Cognitive Functions in Terms of Behavioural, Apoptotic, Cholinergic and Glutamatergic Systems

Aykac, Asli; ÖZBEYLİ, DİLEK; Pekol, Gizem; Sehirli, Ahmet

doi:10.33808/clinexphealthsci.856459

Evaluation of the Effects of Donepezil, Memantine and alpha-lipoic Acid Combined Administration in Amnesia Rats on Impaired Cognitive Functions in Terms of Behavioural, Apoptotic, Cholinergic and Glutamatergic Systems

Aykac A., ÖZBEYLİ D., Pekol G., Sehirli A. O.

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, vol.11, no.4, pp.733-741, 2021 (ESCI)

Publication Type: Article / Article
Volume: 11 Issue: 4
Publication Date: 2021
Doi Number: 10.33808/clinexphealthsci.856459
Journal Name: CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
Page Numbers: pp.733-741
Keywords: Alpha-lipoic acid, amnesia, apoptosis, scopolamine, Y-maze, INDUCED MEMORY IMPAIRMENT, NEUROTROPHIC FACTOR, MUSCARINIC RECEPTORS, OXIDATIVE STRESS, SUBTYPES, MODEL, INFLAMMATION, ANTIOXIDANT, HIPPOCAMPUS, MECHANISMS
Open Archive Collection: AVESIS Open Access Collection
Marmara University Affiliated: Yes

Abstract

Objective: The aim of the study was to evaluate the possible protective effect of donepezil, memantine and alpha-lipoic acid (alpha-LA) combined therapy in the scopolamine-induced amnesia rat model.