This research was performed as a descriptive and analytic study to determine the perceptions of the nurses regarding the computerised physician order entry system. The study was conducted with 207 nurses working in four hospitals using this system in Bursa. Sociodemographic data form and the computerised physician order entry system perception scale were used as data collection tool. Obtained data were analysed by statistical methods and nonparametric tests. The scale met an acceptable level of reliability and validity (alpha = 0.94). There was a statistically significant difference between the groups according to age, position, service and institution, years of institution experience and the period of using the system in terms of scale and sub-dimensions. Finally, it was determined that the nurses perceived the system as positive in spite of some difficulties related to this system. It is suggested that the problems with the system should be solved and training programmes should be organised.