Chemical composition and biological activities of endemic Tripleurospermum conoclinium (Boiss. & Balansa) Hayek essential oils

Servi H., Şen A. , Doğan A.

Flavour And Fragrance Journal, cilt.1, sa.1, ss.1, 2020 (SCI Expanded İndekslerine Giren Dergi)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1 Konu: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1002/ffj.3610
  • Dergi Adı: Flavour And Fragrance Journal
  • Sayfa Sayıları: ss.1


The volatile oils of flowers (TFE), leaves (TLE) and stems (TSE) of Tripleurospermum conoclinium (Boiss. & Balansa) Hayek were obtained by hydrodistillation method for 3 hours with Clevenger‐type apparatus. Chemical composition of oils was determined by GC‐MS analyses. Antidiabetic, anti‐inflammatory and antioxidant activities of oils were tested by α‐glucosidase inhibitory, 5‐lipoxygenase inhibitory and DPPH/ABTS radical scavenging methods, respectively. Eighty‐five constituents were identified in flower oil (78.3%). The major compounds of flower oil were artemisia ketone (10.5%), β‐oplopenone (6.0%), tricosane (4.5%), terpinen‐4‐ol (3.7%) and artemisia alcohol (3.5%). Sixty‐two constituents were identified in leaf oil (67.0%). 1‐octadecanol (11.5%), caryophyllene oxide (5.7%), elemol (3.9%), phytol (3.5%), ledene oxide (3.3%) and artemisia ketone (3.1%) were found as main constituents in the leaf oil. Forty‐six constituents were determined in the stem oil (75.1%). The main compounds of the stem oil were 1‐octadecanol (11.1%), β‐oplopenone (5.5%), ledene oxide (5.5%), caryophyllene oxide (4.4%) and phytol (3.0%). TLE and TSE displayed strong antidiabetic activity with IC50 values of 21.30 and 29.57 µg/mL against α‐glucosidase enzyme, respectively. TLE showed the best anti‐inflammatory activity with an IC50 value of 91.02 µg/mL while TFE and TSE exhibited moderate activity with IC50 values of 186.50 and 257.10 µg/mL, respectively. TFE and TLE were found to possess moderate antioxidant activity with IC50 values of 572.80 and 385.80 µg/mL against ABTS radical while all essential oils showed weak activity against DPPH radical. To the best of our knowledge, this is first report on chemical composition and biological activities of conoclinium essential oils.