Central Sensıtızatıon ın Axıal Spondyloarthrıtıs: An Exploratıve Study wıth Quantıtatıve Sensory Testıng and Clınıcal Scales.

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Yücel F. N., Duruöz M. T.

Modern rheumatology, cilt.32, ss.1137-1145, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1093/mr/roab110
  • Dergi Adı: Modern rheumatology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1137-1145
  • Anahtar Kelimeler: Axial spondyloarthritis, central sensitization, central sensitization inventory, quantitative sensory testing, CONDITIONED PAIN MODULATION, ANKYLOSING-SPONDYLITIS, KNEE OSTEOARTHRITIS, CLASSIFICATION, VALIDATION, THRESHOLD, CRITERIA
  • Marmara Üniversitesi Adresli: Evet

Özet

Objectives To evaluate the central sensitization (CS) and the related parameters in patients with axial spondyloarthritis (axSpA). Methods Quantitative sensory testing (QST) which consists of pressure pain threshold (PPT), temporal summation (TS), and conditioned pain modulation (CPM) were applied to the participants. Disease activity, functional status, sleep quality, pain, depression, and fatigue were assessed. Patients were divided as the ones with and without CS according to the central sensitization inventory (CSI) and the results were compared. Results One hundred patients and 50 controls were recruited. Sixty axSpA patients had CS. When QST results were compared between the patient and control groups, all PPT scores were found lower (p < 0.05) in patients. Regarding the comparison of the patients with and without CS, sacroiliac, and trapezius PPT scores were found lower in the patients with CS (p < 0.05). There was no significant difference between groups in TS values (p > 0.05). All investigated comorbidities were found to be significantly more frequent (p < 0.001) in the patients with CS. Conclusions CS and related comorbidities were found to be increased in axSpA patients. This increase should be taken into consideration in the management of these patients.