Akademik Veri Yönetim Sistemi
Applications of Chemistry in Nanosciences and Biomaterials Engineering NanoBioMat 2025 – Winter Edition, Bucuresti, Romanya, 26 - 28 Kasım 2025, ss.97-98, (Özet Bildiri)
Migraine is a neurological disorder characterized by intense headache attacks that significantly affect patients’ quality of life and productivity. Conventional oral and systemic drug delivery routes often result in delayed onset of action and undesired side effects due to first-pass metabolism. Therefore, intranasal administration has attracted attention as an effective and non-invasive alternative that enables rapid drug absorption and direct transport to the brain via the olfactory and trigeminal pathways.
In this study, three-dimensionally (3D) printed microneedles (MNs) were developed to deliver acetylsalicylic acid (ASA) and Vitamin C through the intranasal route for the treatment of migraine. Gelatin methacryloyl (GelMA) was used as the base matrix material due to its excellent biocompatibility and tunable mechanical properties. The microneedle arrays were fabricated by digital light processing (DLP) 3D printing and characterized by scanning electron microscopy (SEM) to evaluate their morphological integrity. Fourier-transform infrared spectroscopy (FTIR) confirmed the successful incorporation of ASA and Vitamin C into the GelMA matrix. their swelling and degradation behavior were investigated. Their mechanical strength was evaluated through compression testing.
The dual loading of ASA and Vitamin C is expected to provide both analgesic and antioxidant effects, enhancing the therapeutic potential against migraine-related oxidative stress and neuroinflammation. Based on these findings, GelMA-based ASA and Vitamin C loaded microneedles show great promise as an innovative intranasal delivery system for rapid and targeted migraine therapy.