Akademik Veri Yönetim Sistemi
Applications of Chemistry in Nanosciences and Biomaterials Engineering NanoBioMat 2024 - Winter Edition, Bucuresti, Romanya, 27 - 29 Kasım 2024, ss.49, (Özet Bildiri)
Wound dressings are special features used to support wound protection and healing. Since the wound healing process consists of a complex series of biological events, the selection and use of the appropriate wound dressing is of great importance (Sibbald et al., 2019). Melt electrowriting (melt electrowriting) provides an ideal platform for tissue engineering and drug delivery applications by providing controlled fiber production at micro and nano sizes. The double-layered structure used as a wound dressing is designed for both mechanical support and temperature control system. A new double-layered tissue scaffold system with antibacterial cells is designed for wound dressing applications. PCL (polycaprolactone) is a biodegradable polymer and provides long-term mechanical stability of the dressing. The low degradation rate of PCL enables the controlled retention and disintegration of the wound dressing in the body, which allows it to act as a scaffold during the healing process. Morphological characterization of nanofibers produced by melt electrowriting method was performed by scanning electron microscopy (SEM). In addition, functional groups were examined by Fourier transform spectroscopy (FTIR) and the thermal properties of the scaffold were evaluated by differential scanning calorimetry (DSC). Antibacterial activity was confirmed by in vitro antimicrobial tests. The results show that this new double-layer scaffold produced by the PLA-encapsulated amoxicillin method has a promising potential for wound dressing applications. The study may inspire the emergence of advanced wound coatings that support temperature control and tissue regeneration. The electrospray method of amoxicillin and PLA on scaffolds stands out as a method that reduces the risk of wound healing processes and provides controlled drug release. The encapsulated structure of amoxicillin creates an effective barrier against heat-resistant parts, while at the same time maintaining the structural integrity of the wound dressing and supporting the healing process. This new approach has enabled the development of a wound dressing that provides both mechanical strength and climate control. This ability revealed that the developed double-layer scaffold showed high antibacterial activity in in vitro tests and is a promising candidate for tissue engineering applications. As a result, the use of amoxicillin encapsulated with PLA offers an advanced solution that can be a source of new research for wound dressing applications in the future. This developed structure has supported both climate control and tissue regeneration in the wound healing process. Such advanced methods can contribute to the development of new treatment methods that can be more effective in wound treatment and increase the living conditions of patients.