Cyclooxygenase-2 expression in primary and recurrent pterygium

ADIGÜZEL U., Karabacak T., SARI A. A. , öz ö., CİNEL Z. L.

EUROPEAN JOURNAL OF OPHTHALMOLOGY, vol.17, no.6, pp.879-884, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 6
  • Publication Date: 2007
  • Title of Journal : EUROPEAN JOURNAL OF OPHTHALMOLOGY
  • Page Numbers: pp.879-884
  • Keywords: pterygium, primary, recurrent, cyclooxygenase-2, SQUAMOUS-CELL CARCINOMA, INDUCED SKIN TUMORS, MITOMYCIN-C, COX-2 EXPRESSION, CELECOXIB, INHIBITOR, MURINE, CORNEA

Abstract

PURPOSE. Pterygium is a proliferative, inflammatory, and invasive ocular surface disease associated with excessive ultraviolet radiation exposure and has several tumor-like characteristics. Cyclooxygenase-2 (COX-2) is an inducible enzyme and recently increased expression of the enzyme was found in many cancers and premalign lesions. This study was conducted to identify the COX-2 expression in pterygium tissues.