Neuroprotective effects of thymoquinone against spinal cord ischemia-reperfusion injury by attenuation of inflammation, oxidative stress, and apoptosis

Gokce, Emre; Kahveci, Ramazan; Gokce, Aysun; Cemil, Berker; Aksoy, Nurkan; Sargon, Mustafa; Kisa, Ucler; Erdogan, Bulent; Guvenc, YAHYA; Alagoz, Fatih; Kahveci, Ozan

doi:10.3171/2015.10.spine15612

Neuroprotective effects of thymoquinone against spinal cord ischemia-reperfusion injury by attenuation of inflammation, oxidative stress, and apoptosis

Atıf İçin Kopyala

Gokce E. C., Kahveci R., Gokce A., Cemil B., Aksoy N., Sargon M. F., ...Daha Fazla

JOURNAL OF NEUROSURGERY-SPINE, cilt.24, sa.6, ss.949-959, 2016 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 24 Sayı: 6
Basım Tarihi: 2016
Doi Numarası: 10.3171/2015.10.spine15612
Dergi Adı: JOURNAL OF NEUROSURGERY-SPINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.949-959
Anahtar Kelimeler: thymoquinone, methylprednisolone, neuroprotection, spinal cord ischemia-reperfusion injury, oxidative stress, inflammation, apoptosis, spinal cord injury, rat, NIGELLA-SATIVA, SPECTROPHOTOMETRIC METHOD, LIPID-PEROXIDATION, POSSIBLE MECHANISM, RAT, EXPRESSION, OIL, METHYLPREDNISOLONE, ATHEROSCLEROSIS, INHIBITION
Marmara Üniversitesi Adresli: Evet

Özet

OBJECTIVE lschemia-reperfusion (I/R) injury of the spinal cord following thoracoabdominal aortic surgery remains the most devastating complication, with a life-changing impact on the patient. Thymoquinone (TQ), the main constituent of the volatile oil from Nigella sativa seeds, is reported to possess strong antioxidant, antiinflammatory, and antiapoptotic properties. This study investigated the effects of TQ administration following I/R injury to the spinal cord.