Neuroprotective effects of thymoquinone against spinal cord ischemia-reperfusion injury by attenuation of inflammation, oxidative stress, and apoptosis


Gokce E. C. , Kahveci R., Gokce A., Cemil B., Aksoy N., Sargon M. F. , ...Daha Fazla

JOURNAL OF NEUROSURGERY-SPINE, cilt.24, ss.949-959, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 24 Konu: 6
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3171/2015.10.spine15612
  • Dergi Adı: JOURNAL OF NEUROSURGERY-SPINE
  • Sayfa Sayıları: ss.949-959

Özet

OBJECTIVE lschemia-reperfusion (I/R) injury of the spinal cord following thoracoabdominal aortic surgery remains the most devastating complication, with a life-changing impact on the patient. Thymoquinone (TQ), the main constituent of the volatile oil from Nigella sativa seeds, is reported to possess strong antioxidant, antiinflammatory, and antiapoptotic properties. This study investigated the effects of TQ administration following I/R injury to the spinal cord.