Unmet needs in psychiatry and emerging novel pharmacological agents

Cetin M., ARICIOĞLU F.

KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY, cilt.23, sa.3, ss.199-204, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Editöre Mektup
  • Cilt numarası: 23 Sayı: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.5455/bcp.20130927064824
  • Dergi Adı: KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.199-204
  • Anahtar Kelimeler: depression, schizophrenia, drug therapy, treatment-resistant, ketamine, nitroprusside, GLUTAMATE RELEASE, TARGETS, PLASTICITY, MODULATORS, RECEPTORS, RILUZOLE, TRIAL
  • Marmara Üniversitesi Adresli: Evet

Özet

Despite huge amount of efforts and resources spent to improve the pharmacotherapeutic tools to treat major psychiatric disorders such as depression and schizophrenia, there still exist unmet needs in the field. Treatment resistance, non-adherence, and severe adverse effects such as diabetes mellitus type II, extrapyramidal side effects, etc. are among the unmet needs commonly faced by clinicians, probably due to the fact that the pathophysiology of both schizopherenia and depression have not been fully elucidated. Today, neither the monoamine hypothesis of depression nor the dopamine hypothesis of schizophrenia explains either disorder in full. In spite of its widespread presence throughout the brain, the glutamatergic system has remained almost unexplored with respect to drug discovery for psychiatric illnesses.