Evaluation of arterial stiffness and hemodynamics by oscillometric method in patients with systemic sclerosis
Wiener Klinische Wochenschrift, cilt.125, sa.15-16, ss.461-466, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 125 Sayı: 15-16
- Basım Tarihi: 2013
- Doi Numarası: 10.1007/s00508-013-0396-1
- Dergi Adı: Wiener Klinische Wochenschrift
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.461-466
- Anahtar Kelimeler: Arterial stiffness, Pulse wave velocity, Augmentation index, Systemic sclerosis, Oscillometric method, PULSE-WAVE VELOCITY, CARDIOVASCULAR EVENTS, VASCULAR FUNCTION, BLOOD-PRESSURE, TASK-FORCE, ATHEROSCLEROSIS, RISK, ASSOCIATION, INVOLVEMENT, DYSFUNCTION
- Marmara Üniversitesi Adresli: Evet
Özet
Summary: Objectives: Arterial stiffness and its hemodynamic consequences are associated with adverse cardiovascular events. Pulse wave velocity (PWV) and augmentation index (AIx) are noninvasive markers of arterial stiffness. Systemic sclerosis (SSc) is a systemic, autoimmune disease affecting mainly the small vessels. The aim of this study was to evaluate the arterial stiffness parameters and hemodynamics by oscillometric method in patients with SSc. Methods: Thirty-five consecutive patients with diagnosed SSc and 35 age- and sex-matched healthy controls were included in the study. Measurements of arterial stiffness were carried out by using a Mobil-O-Graph arteriograph system that detected signals from the brachial artery. Results: While hemodynamic parameters were not statistically significant between SSc and control groups, heart rate was significantly higher in SSc group (84 ± 12 and 72 ± 7 bpm, p = 0.001). SSc patients had significantly higher AIx and PWV values compared with controls (27.9 ± 12.4 versus 21.0 ± 11.4 %, p = 0.019 and 6.56 ± 1.5 versus 5.04 ± 0.17 m/s, p < 0.001, respectively). PWV was significantly associated with SSc when adjusted by heart rate (p = 0.001, Odds ratio (OR): 17.304, 95 % confidence interval (CI): 3.225-92.832). Conclusions: PWV and AIx were significantly higher in patients with SSc. Measurement of arterial stiffness parameters using oscillometric method was reliable, reproducible and easy in patients with SSc. © 2013 Springer-Verlag Wien.