A novel approach in allergen-specific immunotherapy: Combination of sublingual and subcutaneous routes

Keles S., Karakoc-Aydiner E., Ozen A. O., Izgi A. G., Tevetoglu A., AKKOÇ T., ...More

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol.128, no.4, pp.808-822, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 128 Issue: 4
  • Publication Date: 2011
  • Doi Number: 10.1016/j.jaci.2011.04.033
  • Journal Name: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.808-822
  • Keywords: Children, cytokine, Der p 1, subcutaneous immunotherapy, sublingual immunotherapy, GRASS-POLLEN IMMUNOTHERAPY, DOUBLE-DUMMY, DOUBLE-BLIND, BEE VENOM, ASTHMA, RESPONSES, EFFICACY, RHINITIS, IGG, MECHANISMS
  • Marmara University Affiliated: Yes

Abstract

Background: Subcutaneous allergen-specific immunotherapy (SIT) has an early onset of action, whereas repeated injections and safety concerns have limited its use in the pediatric age group. Meanwhile, the improved safety profile of the sublingual route has been accepted as an alternative despite its relatively late onset of action.