In utero prednisone exposure affects genital development


YÜCEL S. , Desouza A., Baskin L.

JOURNAL OF UROLOGY, vol.172, no.4, pp.1725-1730, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 172 Issue: 4
  • Publication Date: 2004
  • Doi Number: 10.1097/01.ju.0000139911.56346.1b
  • Title of Journal : JOURNAL OF UROLOGY
  • Page Numbers: pp.1725-1730

Abstract

Purpose: The etiology of the worldwide incidence of hypospadias remains unexplained. Data from the Center for Disease Control suggest that maternal asthma exposure may be a risk factor. The development of the mouse and human urethra shows significant similarities, such as fusion of 2 epithelial edges, closure of a midline epithelial seam and subsequent cellular remodeling, to justify the use of the mouse as an experimental animal model. Prednisone may act as a weak androgen directly or alternatively lowering testosterone by hypothalamic suppression of gonadotropins. We describe the effects of prednisone on urethral formation in the mouse.