In utero prednisone exposure affects genital development

YÜCEL S., Desouza A., Baskin L.

JOURNAL OF UROLOGY, cilt.172, sa.4, ss.1725-1730, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 172 Sayı: 4
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1097/01.ju.0000139911.56346.1b
  • Dergi Adı: JOURNAL OF UROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1725-1730
  • Marmara Üniversitesi Adresli: Hayır

Özet

Purpose: The etiology of the worldwide incidence of hypospadias remains unexplained. Data from the Center for Disease Control suggest that maternal asthma exposure may be a risk factor. The development of the mouse and human urethra shows significant similarities, such as fusion of 2 epithelial edges, closure of a midline epithelial seam and subsequent cellular remodeling, to justify the use of the mouse as an experimental animal model. Prednisone may act as a weak androgen directly or alternatively lowering testosterone by hypothalamic suppression of gonadotropins. We describe the effects of prednisone on urethral formation in the mouse.