Akademik Veri Yönetim Sistemi
Journal of Oncological Science, cilt.11, sa.2, ss.175-178, 2025 (Scopus, TRDizin)
Thyroid cancers are rare, accounting for 2-3% of all malignancies. They are usually asymptomatic and incidentally detected. Histopathologic evaluation should be performed for definitive diagnosis. A 60-year-old woman with rectal cancer was found to have a 3 cm thyroid nodule on positron emission tomography/computed tomography. While the first biopsy was benign, a second biopsy showed a follicular lesion of uncertain significance. Despite lung lesion regression, the thyroid lesion progressed, leading to a left lobectomy. Pathology revealed the thyroid lesion as metastatic intestinal-type adenocarcinoma, which is related to poorly differentiated thyroid carcinoma. This changed her treatment plan for metastatic rectal cancer. The case underscores the importance of considering metastasis in thyroid nodules, especially in patients with other cancers like colorectal cancer. It highlights the need for thorough differential diagnosis, recognize the potential for thyroid malignancy, and the role of thyroidectomy in cases where biopsy results are inconclusive. This case is remarkable for representing a tumor-to-tumor metastasis, where colorectal adenocarcinoma metastasized into a primary poorly differentiated thyroid carcinoma-an exceedingly rare phenomenon. The diagnostic complexity, including inconclusive fine needle aspiration biopsies and delayed progression despite systemic treatment, underscores the importance of maintaining a high index of suspicion when evaluating thyroid nodules in patients with known malignancies.