Determination of fosfomycin susceptibility in carbapenemase producing K. pneumoniae strains isolated prior to clinical use of the intravenous formulation in Turkey

Altinkanat Gelmez G., Can B., Ertürk Şengel B., Korten V., Söyledir G.

Marmara Medical Journal, vol.34, no.2, pp.127-131, 2021 (ESCI, Scopus, TRDizin) identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.5472/marumj.942784
  • Journal Name: Marmara Medical Journal
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.127-131
  • Keywords: Fosfomycin susceptibility, Carbapenemase-producing Klebsiella pneumoniae, KLEBSIELLA-PNEUMONIAE, RESISTANT ENTEROBACTERIACEAE, EMERGENCE, COLISTIN
  • Marmara University Affiliated: Yes

Abstract

Objectives: The incidence of infections caused by carbapenem-resistant Enterobacteriaceae has increased worldwide. Limitations in the development of new antimicrobial agents have led clinicians to reconsider the clinical efficiency of old antibiotics, such as intravenous formulation of fosfomycin, in the treatment of multidrug-resistant Gram-negative bacterial infections. We investigated the fosfomycin susceptibility of carbapenemase-producing Klebsiella pneurnoniae strains isolated prior to the clinical use of the intraveno US formulation of fosfomycin in Turkey.