Significance of H3K27M mutation with specific histomorphological features and associated molecular alterations in pediatric high-grade glial tumors

Bozkurt S. U., Dagcinar A., Tanrikulu B., Comunoglu N., Meydan B. C., Ozek M., ...Daha Fazla

CHILDS NERVOUS SYSTEM, cilt.34, sa.1, ss.107-116, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1007/s00381-017-3633-5
  • Dergi Adı: CHILDS NERVOUS SYSTEM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.107-116
  • Anahtar Kelimeler: ATRX, p53, Histomorphology, BRAF V600E, INTRINSIC PONTINE GLIOMA, GENETIC ALTERATIONS, K27M MUTATION, HISTONE H3.3, BRAF V600E, H3F3A, SUBGROUPS, GLIOBLASTOMAS, IDH1, INHIBITION
  • Marmara Üniversitesi Adresli: Evet

Özet

Pediatric high-grade gliomas (pHGGs) constitute almost 15% of all childhood brain tumors. Recurrent mutations such as H3K27M mutation in H3F3A and HIST1H3B genes encoding histone H3 and its variants were identified in approximately 30% of pediatric glioblastomas. This study aimed to ascertain the morphological and molecular characteristics of pHGGs with H3K27M mutation.