Dental follicle mesenchymal stem cells down-regulate Th2-mediated immune response in asthmatic patients mononuclear cells.

Genc, D.; Zibandeh, N.; Nain, E.; Gokalp, M.; Ozen, AHMET; Goker, MEHMET; Akkoc, TUNÇ

doi:10.1111/cea.13126

Dental follicle mesenchymal stem cells down-regulate Th2-mediated immune response in asthmatic patients mononuclear cells.

Genc D., Zibandeh N., Nain E., Gokalp M., Ozen A. O., Goker M. K., ...Daha Fazla

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, cilt.48, sa.6, ss.663-678, 2018 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 48 Sayı: 6
Basım Tarihi: 2018
Doi Numarası: 10.1111/cea.13126
Dergi Adı: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.663-678
Anahtar Kelimeler: asthma, dental follicle mesenchymal stem cells, house dust mite, immunomodulation, T-CELLS, IMMUNOMODULATION, IMMUNOTHERAPY, PHENOTYPES, ALLERGY, CD86
Marmara Üniversitesi Adresli: Evet

Özet

BackgroundAsthma is a chronic inflammatory disease in which inflammatory responses have the polarisation of CD4(+) T cells to Th2 cells. Dental follicle mesenchymal stem cells (DFSCs) have strong anti-inflammatory properties comparable to other mesenchymal stem cells.