Store-operated Ca2+ influx in airway smooth muscle - Interactions between volatile anesthetic and cyclic nucleotide effects


Prakash Y. S. , Iyanoye A., Ay B., Sieck G. C. , Pabelick C. M.

ANESTHESIOLOGY, cilt.105, sa.5, ss.976-983, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Background Volatile anesthetics produce bronchodilation in part by depleting sarcoplasmic reticulum Ca2+ stores in airway smooth muscle (ASM). Other bronchodilatory drugs are known to act via cyclic nucleotides (cyclic adenosine 3',5'-cyclic monophosphate, cyclic guanosine 3',5'-cyclic monophosphate). Intracellular Ca2+ regulation in ASM involves plasma membrane Ca2+ influx, including that triggered by sarcoplasmic reticulum Ca2+ depletion (store-operated Ca2+ entry [SOLED. The authors hypothesized that anesthetics and bronchodilatory agents interact in inhibiting SOLE, thus enhancing ASM relaxation.