Assessment of antiangiogenic effect of imatinib mesylate on vestibular schwannoma tumors using in vivo corneal angiogenesis assay Laboratory investigation


Yener U., Avsar T., Akgun E., Seker A., BAYRİ Y. , Kilic T.

JOURNAL OF NEUROSURGERY, cilt.117, ss.697-704, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 117 Konu: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.3171/2012.6.jns112263
  • Dergi Adı: JOURNAL OF NEUROSURGERY
  • Sayfa Sayıları: ss.697-704

Özet

Object. Angiogenesis and the platelet-derived growth factor (PDGF) pathway are active in the pathogenesis of vestibular schwannomas (VSs). The purpose of this study was to test whether imatinib mesylate (Gleevec), a PDGF receptor (PDGFR) blocker, reduces angiogenic capacity in sporadic VS and in VS associated with neurofibromatosis Type 2 (NF2) using a conical angiogenesis assay.