Atıf İçin Kopyala
Yener U., Avsar T., Akgun E., Seker A., BAYRİ Y., Kilic T.
JOURNAL OF NEUROSURGERY, cilt.117, sa.4, ss.697-704, 2012 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
117
Sayı:
4
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Basım Tarihi:
2012
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Doi Numarası:
10.3171/2012.6.jns112263
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Dergi Adı:
JOURNAL OF NEUROSURGERY
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Sayfa Sayıları:
ss.697-704
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Anahtar Kelimeler:
angiogenesis, corneal angiogenesis assay, oncology, vestibular schwannoma, neurofibromatosis Type 2, ENDOTHELIAL GROWTH-FACTOR, ACOUSTIC NEUROMAS, TYROSINE KINASE, FACTOR RECEPTOR, STEREOTACTIC RADIOSURGERY, NEUROFIBROMATOSIS TYPE-2, TARGETING ANGIOGENESIS, TAMING GLIOBLASTOMA, CLINICAL-ASPECTS, PDGF RECEPTORS
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Marmara Üniversitesi Adresli:
Evet
Özet
Object. Angiogenesis and the platelet-derived growth factor (PDGF) pathway are active in the pathogenesis of vestibular schwannomas (VSs). The purpose of this study was to test whether imatinib mesylate (Gleevec), a PDGF receptor (PDGFR) blocker, reduces angiogenic capacity in sporadic VS and in VS associated with neurofibromatosis Type 2 (NF2) using a conical angiogenesis assay.