Stable hemiaminals from axially chiral pyridine compounds

Tuncel S. T., Demir I., ERDEM S., Dogan I.

Chirality, vol.35, no.6, pp.365-375, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 6
  • Publication Date: 2023
  • Doi Number: 10.1002/chir.23545
  • Journal Name: Chirality
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Applied Science & Technology Source, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, Chimica, EMBASE, MEDLINE
  • Page Numbers: pp.365-375
  • Keywords: 2-iminothiazolidin-4-ol, axially chiral hemiaminal, intramolecular hydrogen bonding, pyridine compounds, stable hemiaminal, ONE-POT SYNTHESIS, COMPUTATIONAL INSIGHT, DENSITY FUNCTIONALS, DERIVATIVES, REDUCTION, KINETICS
  • Marmara University Affiliated: Yes

Abstract

© 2023 Wiley Periodicals LLC.In this study, we have synthesized a series of 3-(pyridin-2-yl)-2-(pyridin-2-ylimino)thiazolidin-4-ol derivatives regioselectively from 2-iminothiazolidin-4-ones using LiAlH4 at room temperature. Due to the presence of the restricted rotation around the N3-Caryl single bond, the formation of M/P isomers was observed. The OH group of the hemiaminal was found to orient itself on the same side with pyridyl nitrogen during this restricted rotation to form an intramolecular hydrogen bond, which was demonstrated by the computational DFT study. This orientation presumably inhibited the occurrence of dehydration and stabilized the molecule.