Histomorphological Changes of Apelin Treatment in Renal Tissue in Doxorubicin-induced Nephrotic Syndrome Model

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Atıf İçin Kopyala

ÖZKAN N., Sehirli A. O., KOÇ M., ÇETİNEL Ş.

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, cilt.6, sa.1, ss.20-27, 2016 (ESCI)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 6 Sayı: 1
• Basım Tarihi: 2016
• Doi Numarası: 10.5152/clinexphealthsci.2016.060
• Dergi Adı: CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
• Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
• Sayfa Sayıları: ss.20-27
• Marmara Üniversitesi Adresli: Evet

Özet

Objective: Nephrotic syndrome (NS) may result in renal failure. Apelin (AP), a vasoactive peptide, demonstrates its effect by binding to the AP receptor. AP, present in the endothelial and vascular smooth muscle cells of glomerular arterioles, affects the pre- and post-microvascularization by regulating renal hemodynamics. This study aimed to determine the histomorphological changes of AP treatment in a doxorubicin (DOX)-induced NS model.