Histomorphological Changes of Apelin Treatment in Renal Tissue in Doxorubicin-induced Nephrotic Syndrome Model


ÖZKAN N. , Sehirli A. O. , KOÇ M. , ÇETİNEL Ş.

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, cilt.6, sa.1, ss.20-27, 2016 (ESCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 6 Konu: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5152/clinexphealthsci.2016.060
  • Dergi Adı: CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
  • Sayfa Sayıları: ss.20-27

Özet

Objective: Nephrotic syndrome (NS) may result in renal failure. Apelin (AP), a vasoactive peptide, demonstrates its effect by binding to the AP receptor. AP, present in the endothelial and vascular smooth muscle cells of glomerular arterioles, affects the pre- and post-microvascularization by regulating renal hemodynamics. This study aimed to determine the histomorphological changes of AP treatment in a doxorubicin (DOX)-induced NS model.