Melatonin Expresses Powerful Anti-inflammatory and Antioxidant Activities Resulting in Complete Improvement of Acetic-Acid-Induced Colitis in Rats

Tahan G., Gramignoli R., Marongiu F., Aktolga S., Cetinkaya A., Tahan V., ...Daha Fazla

DIGESTIVE DISEASES AND SCIENCES, cilt.56, sa.3, ss.715-720, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Sayı: 3
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1007/s10620-010-1364-5
  • Dergi Adı: DIGESTIVE DISEASES AND SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.715-720
  • Anahtar Kelimeler: Melatonin, Ulcerative colitis, Inflammatory bowel disease, Oxidative stress, Tumor necrosis factor, Cytokine, INFLAMMATORY-BOWEL-DISEASE, ULCERATIVE-COLITIS, BLOOD-PLASMA, VITAMIN-E, INJURY, DEFENSES, COLON, ASSAY, SHOCK
  • Marmara Üniversitesi Adresli: Evet

Özet

Increased free-radical production, decreased antioxidant capacity, and excessive inflammation are well-known features in the pathogenesis of inflammatory bowel disease. Melatonin is a powerful antioxidant and a scavenger of hydroxyl radicals. Melatonin has also been shown to have anti-inflammatory activities in tissues. Our study objective is to investigate the effects of melatonin on tissue inflammatory activities using an ulcerative colitis (UC) model induced by acetic acid (AA) in rats.