Exposure to continuous darkness ameliorates gastric and colonic inflammation in the rat: Both receptor and non-receptor-mediated processes


Cevik H., Erkanli G., Ercan F. , Isman C., Yegen B.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol.20, no.2, pp.294-303, 2005 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 2
  • Publication Date: 2005
  • Doi Number: 10.1111/j.1400-1746.2005.03579.x
  • Title of Journal : JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
  • Page Numbers: pp.294-303
  • Keywords: darkness, gastrointestinal inflammation, glutathione, malonaldialdehyde, melatonin, INDUCED COLITIS, PINEAL-GLAND, MELATONIN, ANTIOXIDANT, MODULATION, RHYTHMS, STRESS, CANCER, TRACT

Abstract

Background and Aim: Melatonin is a hormone involved in the transduction of photoperiodic information, and appears to modulate a variety of neural and endocrine functions. The present study was designed to determine the impact of continuous darkness (CD) on acute gastric and colonic inflammation and the involvement of melatonin receptors in the darkness-related alterations in oxidant gut injury.