Regulation of the acid-labile subunit of the insulin-like growth factor ternary complex in patients with insulin-dependent diabetes mellitus and severe burns

BEREKET A., Wilson T., Blethen S., Sakurai Y., Herndon D., Wolfe R., ...More

CLINICAL ENDOCRINOLOGY, vol.44, no.5, pp.525-532, 1996 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 5
  • Publication Date: 1996
  • Doi Number: 10.1046/j.1365-2265.1996.726547.x
  • Journal Name: CLINICAL ENDOCRINOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.525-532
  • Marmara University Affiliated: No

Abstract

OBJECTIVE Little information is available regarding the regulation of serum acid-labile subunit (ALS) in human disease, We have studied alterations in serum ALS of the insulin-like growth factor (IGF) ternary complex in children with untreated insulin-dependent diabetes mellitus (IDDM) and subjects with severe burns before and after insulin therapy. In addition, we have investigated the effect of insulin plus GH on serum ALS in burn patients.