Caprylic acid ameliorates rotenone induced inflammation and oxidative stress in the gut-brain axis in Zebrafish

Cansiz D., Unal I., Ustundag U. V., Alturfan A. A., Altinoz M. A., ELMACI I., ...Daha Fazla

MOLECULAR BIOLOGY REPORTS, cilt.48, sa.6, ss.5259-5273, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Sayı: 6
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/s11033-021-06532-5
  • Dergi Adı: MOLECULAR BIOLOGY REPORTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.5259-5273
  • Anahtar Kelimeler: Parkinson's Disease, Caprylic acid, Zebrafish, Rotenone, MEDIUM-CHAIN TRIGLYCERIDES, NEUROTROPHIC FACTOR, PARKINSONS-DISEASE, EXPRESSION, INTESTINE, PLASMA, MODEL, TOOL, RICH, OIL
  • Marmara Üniversitesi Adresli: Evet

Özet

Background Dysfunction of the gastrointestinal tract (GIT) is one of the most common non-motor symptom of Parkinson's Disease (PD). Pathological processes causing PD were suggested to initiate in the enteric nervous system (ENS) and proceed to the central nervous system (CNS). There are studies showing that low-carbohydrate ketogenic diets can improve motor symptoms of PD. Caprylic acid (C8) is the principal fatty acid component of the medium-chain triglycerides in the ketogenic diets. In this study, we aimed to evaluate the effects of caprylic acid, in neurotoxin exposed zebrafish focusing on the relationship between intestinal and brain oxidative stress and inflammation.