Evaluation of oxidant stress in chronic hemodialysis patients: use of different parameters.


HAKLAR G. , YEGENAGA I., YALCIN A. S.

Clinica chimica acta; international journal of clinical chemistry, cilt.234, ss.109-14, 1995 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 234
  • Basım Tarihi: 1995
  • Doi Numarası: 10.1016/0009-8981(94)05982-x
  • Dergi Adı: Clinica chimica acta; international journal of clinical chemistry
  • Sayfa Sayıları: ss.109-14

Özet

Patients with chronic renal failure, particularly those undergoing regular dialysis treatment (RDT) are candidates for free radical damage. It is difficult to quantitate free radicals because of their short half-lives and reactive nature. Therefore, indirect methods measuring products of lipid peroxidation and protein oxidation are preferred. The present study displays a profile of lipid peroxidation and protein oxidation parameters, which are more sensitive and specific than the widely used method measuring thiobarbituric acid reactive substances (TBARS), adapted to the plasma and erythrocyte samples of RDT patients. We have observed increased levels of plasma and erythrocyte lipid peroxidation and also demonstrated increased protein oxidation in erythrocyte membranes of RDT patients.