Effect of MDR1 Polymorphisms on the Blood Concentrations of Tacrolimus in Turkish Renal Transplant Patients

Ciftci H. S., Ayna T. K., Caliskan Y. K., Guney I., Bakkaloglu H., Nane I., ...Daha Fazla

TRANSPLANTATION PROCEEDINGS, cilt.45, sa.3, ss.895-900, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.transproceed.2013.02.055
  • Dergi Adı: TRANSPLANTATION PROCEEDINGS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.895-900
  • Marmara Üniversitesi Adresli: Evet

Özet

Background. Tacrolimus, a calcineurin inhibitor, is prescribed to prevent allograft rejection in renal transplantation. Tacrolimus not only has a narrow therapeutic index, but also shows significant interindividual differences. The absorption and metabolism of this drug are affected by multidrug resistance (MDR) 1 gene polymorphisms that correlated with single-nucleotide polymorphisms (SNPs) affecting in vivo P-glycoprotein activity. This study investigated associations of MDR1 gene C3435T polymorphism with tacrolimus blood concentrations and dose requirements as well as acute rejection episodes among Turkish renal transplant patients.