Correlations between amygdala volumes and serum levels of BDNF and NGF as a neurobiological markerin adolescents with bipolar disorder

Inal-Emiroglu F. N., Karabay N., Resmi H., Guleryuz H., Baykara B., Alsen S., ...More

JOURNAL OF AFFECTIVE DISORDERS, vol.182, pp.50-56, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 182
  • Publication Date: 2015
  • Doi Number: 10.1016/j.jad.2015.04.016
  • Journal Name: JOURNAL OF AFFECTIVE DISORDERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.50-56
  • Keywords: Amygdala volumes, BDNF, NGF, Adolescents, Bipolar disorder, NEUROTROPHIC FACTOR, YOUNG-ADULTS, CELL-DEATH, ABNORMALITIES, METAANALYSIS, MORPHOMETRY
  • Marmara University Affiliated: No

Abstract

Background: The amygdala is repeatedly implicated as a critical component of the neurocircuitry regulating emotional valence. Studies have frequently reported reduced amygdala volumes in children and adolescents with bipolar disorder (BD). Brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) play critical roles in growth, differentiation, maintenance, and synaptic plasticity of neuronal systems in adolescent brain development. The aim of the present study was to assess amygdala volumesand its correlation with serum levels of NGF and BDNF in euthymic adolescents with BD and healthy controls.