Uridine protects against hypoxic-ischemic brain injury by reducing histone deacetylase activity in neonatal rats


KOYUNCUOĞLU T. , TÜRKYILMAZ M., GÖREN B., ÇETİNKAYA M., CANSEV M., ALKAN T.

RESTORATIVE NEUROLOGY AND NEUROSCIENCE, cilt.33, sa.5, ss.777-784, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 33 Konu: 5
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3233/rnn-150549
  • Dergi Adı: RESTORATIVE NEUROLOGY AND NEUROSCIENCE
  • Sayfa Sayıları: ss.777-784

Özet

Purpose: A significant cause of neurological disability in newborns is hypoxic-ischemic encephalopathy (HIE), a disorder which involves an enhancement in histone deacetylase (HDAC) activity among underlying pathological mechanisms. We showed recently that exogenous administration of uridine to newborn rats with HIE reduced brain injury in a dose-dependent manner. The present study was performed to investigate whether uridine modulates histone acetylation/deacetylation balance in a neonatal rat model of HIE.