Growth Arrest-Specific 6 (Gas6) and TAM Receptors in Mouse Platelets


Uras F., Kucuk B., BİNGÖL ÖZAKPINAR Ö. , DEMİR A. M.

TURKISH JOURNAL OF HEMATOLOGY, cilt.32, sa.1, ss.58-63, 2015 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 32 Konu: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.4274/tjh.2013.0097
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Sayfa Sayıları: ss.58-63

Özet

Objective: Growth arrest-specific 6 (Gas6) is a newly discovered vitamin K-dependent protein, which is a ligand for TAM receptors [Tyro3 (Sky), Axl, and Mer] from the tyrosine kinase family. Gas6 knockout mice were resistant to venous and arterial thrombosis. There are contradictory reports on the presence of Gas6 and its receptors in mouse platelets. The objective of this study was to investigate whether Gas6 and its receptors were present in mouse platelets or not.