Akademik Veri Yönetim Sistemi
Applications of Chemistry in Nanosciences and Biomaterials Engineering NanoBioMat 2023 – Winter Edition, Bucuresti, Romanya, 22 - 24 Kasım 2023, ss.79
This study aims to develop Gelatin Methacryloyl (GelMA)-based symblepharon rings with added Lascorbic acid (Vc) and controlled release of vitamin for the treatment of the ocular surface, corneal healing,
and epithelial growth acceleration, while also preventing possible inflammation. The patient's need for
systemic Vc intake was eliminated, and potential problems such as dryness in the eyes due to ocular burns
were prevented. In addition, problems such as the inability to manufacture commercially available
symblepharon rings and the time-consuming delivery to the patient after production were facilitated by the
3D printing DLP technology to be used within the scope of the article, and personalized products were
developed in a short time This innovative approach also facilitated the production of rings that exhibit
superior flexibility and softness, and are amenable to the mechanical movements of the patient. As a result,
it was aimed to alleviate the patient's discomfort and possible complications in terms of the ring's release
mechanical durability, thermal, degradation, vitamin C release feature, and biocompatibility. Moreover, it
was shown that GelMA hydrogel can be produced by 3D printing, which might promote epithelialization,
is mechanically compatible with epithelial tissue, and provides a moist environment. Furthermore, the
produced symblepharon rings possessed unique values, displayed innovative approaches, and contributed
new data to the literature.