Protective effect of MESNA (2-mercaptoethane sulfonate) against hepatic ischemia/reperfusion injury in rats

Sener G., Sehirli O., Ercan F., Sirvanci S., Gedik N., Kacmaz A.

SURGERY TODAY, vol.35, no.7, pp.575-580, 2005 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 7
  • Publication Date: 2005
  • Doi Number: 10.1007/s00595-004-2985-0
  • Journal Name: SURGERY TODAY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.575-580
  • Keywords: 2-mercaptoethane sulfonate, ischemia/reperfusion, liver, oxidative damage, REPERFUSION INJURY, MYELOPEROXIDASE ACTIVITY, ISCHEMIA-REPERFUSION, LIPID-PEROXIDATION, REACTIVE OXYGEN, TISSUE-INJURY, FREE-RADICALS, MELATONIN, ANTIOXIDANT, MECHANISMS
  • Marmara University Affiliated: Yes

Abstract

Purpose. Reoxygenation of ischemic tissue generates various reactive oxygen metabolites (ROMs), which have a deleterious effect on various cellular functions. We evaluated the possible protective effect of 2-mercaptoethane sulfonate (MESNA) on hepatic ischemia/reperfusion (I/R) injury.