Protective effect of MESNA (2-mercaptoethane sulfonate) against hepatic ischemia/reperfusion injury in rats

Sener, GÖKSEL; Sehirli, O; Ercan, FERİHA; Sirvanci, SERAP; Gedik, N; Kacmaz, A

doi:10.1007/s00595-004-2985-0

Protective effect of MESNA (2-mercaptoethane sulfonate) against hepatic ischemia/reperfusion injury in rats

Sener G., Sehirli O., Ercan F., Sirvanci S., Gedik N., Kacmaz A.

SURGERY TODAY, cilt.35, sa.7, ss.575-580, 2005 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 35 Sayı: 7
Basım Tarihi: 2005
Doi Numarası: 10.1007/s00595-004-2985-0
Dergi Adı: SURGERY TODAY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.575-580
Anahtar Kelimeler: 2-mercaptoethane sulfonate, ischemia/reperfusion, liver, oxidative damage, REPERFUSION INJURY, MYELOPEROXIDASE ACTIVITY, ISCHEMIA-REPERFUSION, LIPID-PEROXIDATION, REACTIVE OXYGEN, TISSUE-INJURY, FREE-RADICALS, MELATONIN, ANTIOXIDANT, MECHANISMS
Marmara Üniversitesi Adresli: Evet

Özet

Purpose. Reoxygenation of ischemic tissue generates various reactive oxygen metabolites (ROMs), which have a deleterious effect on various cellular functions. We evaluated the possible protective effect of 2-mercaptoethane sulfonate (MESNA) on hepatic ischemia/reperfusion (I/R) injury.