Synthesis, characterization and biological evaluation of some novel sulfonylurea derivatives

TOK F., Cihangir H., Şan K., Çakir C., Tuna K., Sicak Y., ...Daha Fazla

Journal of Research in Pharmacy, cilt.27, sa.6, ss.2416-2424, 2023 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 6
  • Basım Tarihi: 2023
  • Doi Numarası: 10.29228/jrp.529
  • Dergi Adı: Journal of Research in Pharmacy
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.2416-2424
  • Anahtar Kelimeler: antioxidant, cholinesterase, Sulfonylurea, tyrosinase, α-amylase, α-glucosidase
  • Marmara Üniversitesi Adresli: Evet

Özet

In this study, some new sulfonylurea derivatives based on the sulfanilamide compound were synthesized. IR,1H-NMR,13C-NMR spectroscopic methods and elemental analysis data were used to confirm the structures of the synthesized compounds. ABTS, DPPH, Cuprac and β-Carotene/linoleic acid assays were performed to evaluate the antioxidant activities of sulphonylurea derivatives. The activities of these compounds against some enzymes (acetylcholinesterase, butrylcholinesterase, tyrosinase, α-amylase and α-glucosidase) were also investigated. Compounds S7, S8, S13 and S14 showed inhibitory activity against α-amylase enzyme with IC50 values of 227.84±1.48-298.27±8.61 µM. In addition, the drug-likeness properties and solubility of the compounds were determined by computational programs.