Synthesis, characterization and biological evaluation of some novel sulfonylurea derivatives

TOK F., Cihangir H., Şan K., Çakir C., Tuna K., Sicak Y., ...More

Journal of Research in Pharmacy, vol.27, no.6, pp.2416-2424, 2023 (ESCI, Scopus, TRDizin) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 6
  • Publication Date: 2023
  • Doi Number: 10.29228/jrp.529
  • Journal Name: Journal of Research in Pharmacy
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.2416-2424
  • Keywords: antioxidant, cholinesterase, Sulfonylurea, tyrosinase, α-amylase, α-glucosidase
  • Marmara University Affiliated: Yes

Abstract

In this study, some new sulfonylurea derivatives based on the sulfanilamide compound were synthesized. IR,1H-NMR,13C-NMR spectroscopic methods and elemental analysis data were used to confirm the structures of the synthesized compounds. ABTS, DPPH, Cuprac and β-Carotene/linoleic acid assays were performed to evaluate the antioxidant activities of sulphonylurea derivatives. The activities of these compounds against some enzymes (acetylcholinesterase, butrylcholinesterase, tyrosinase, α-amylase and α-glucosidase) were also investigated. Compounds S7, S8, S13 and S14 showed inhibitory activity against α-amylase enzyme with IC50 values of 227.84±1.48-298.27±8.61 µM. In addition, the drug-likeness properties and solubility of the compounds were determined by computational programs.