Usage of 3D-Printed Scaffolds Manufactured with Bio-Based Photopolymer Resin Via 3D DLP in Tissue Engineering

Tezel Ö., KAHRAMAN M. V., Ceylan R., Açıksarı A., Demir E., Çetinel S.

Journal of Polymers and the Environment, cilt.33, sa.7, ss.3013-3028, 2025 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 7
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1007/s10924-025-03592-7
  • Dergi Adı: Journal of Polymers and the Environment
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, Aerospace Database, Agricultural & Environmental Science Database, BIOSIS, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, Environment Index, Geobase, Greenfile, Metadex, Pollution Abstracts, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.3013-3028
  • Anahtar Kelimeler: 3D printing, 3D scaffold, Fibroblast, Photo-DSC, Photopolymerization, Tissue Engineering
  • Marmara Üniversitesi Adresli: Evet

Özet

In this study, three-dimensional (3D) printed scaffolds were fabricated using a bio-based photopolymer resin derived from sustainable resources for tissue engineering applications. The resin consisted of a UV-curable bio-based fatty acid-based polyester acrylate, polyethylene glycol dimethacrylate, and a photoinitiator. To enhance porosity and biodegradability, coconut oil and poly(ethylene glycol) (PEG) were incorporated into the formulations. The curing behavior of different formulations was investigated by differential photocalorimetry (Photo-DSC), and it was observed that polyethylene glycol accelerated the curing process. The biocompatibility of the 3D printed scaffolds was evaluated using culture experiments with mouse fibroblast (L-929) cells. The obtained results demonstrate that the developed bio-based photopolymer resins have the potential to be a promising material for tissue engineering applications.