Usage of 3D-Printed Scaffolds Manufactured with Bio-Based Photopolymer Resin Via 3D DLP in Tissue Engineering

Tezel Ö., KAHRAMAN M. V., Ceylan R., Açıksarı A., Demir E., Çetinel S.

Journal of Polymers and the Environment, vol.33, no.7, pp.3013-3028, 2025 (SCI-Expanded, Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 7
  • Publication Date: 2025
  • Doi Number: 10.1007/s10924-025-03592-7
  • Journal Name: Journal of Polymers and the Environment
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, Aerospace Database, Agricultural & Environmental Science Database, BIOSIS, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, Environment Index, Geobase, Greenfile, Metadex, Pollution Abstracts, Civil Engineering Abstracts
  • Page Numbers: pp.3013-3028
  • Keywords: 3D printing, 3D scaffold, Fibroblast, Photo-DSC, Photopolymerization, Tissue Engineering
  • Marmara University Affiliated: Yes

Abstract

In this study, three-dimensional (3D) printed scaffolds were fabricated using a bio-based photopolymer resin derived from sustainable resources for tissue engineering applications. The resin consisted of a UV-curable bio-based fatty acid-based polyester acrylate, polyethylene glycol dimethacrylate, and a photoinitiator. To enhance porosity and biodegradability, coconut oil and poly(ethylene glycol) (PEG) were incorporated into the formulations. The curing behavior of different formulations was investigated by differential photocalorimetry (Photo-DSC), and it was observed that polyethylene glycol accelerated the curing process. The biocompatibility of the 3D printed scaffolds was evaluated using culture experiments with mouse fibroblast (L-929) cells. The obtained results demonstrate that the developed bio-based photopolymer resins have the potential to be a promising material for tissue engineering applications.