The risk factors of colistin methanesulfonate associated nephrotoxicity

TİGEN E., Koltka E. N., Dogru A., Gura M., Vahabaoglu H.

INDIAN JOURNAL OF CRITICAL CARE MEDICINE, cilt.20, sa.6, ss.353-356, 2016 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 6
  • Basım Tarihi: 2016
  • Doi Numarası: 10.4103/0972-5229.183905
  • Dergi Adı: INDIAN JOURNAL OF CRITICAL CARE MEDICINE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.353-356
  • Anahtar Kelimeler: Colistin methanesulfonate, nephrotoxicity, risk factors, COHORT, SODIUM
  • Marmara Üniversitesi Adresli: Evet

Özet

Purpose: The risk factors of colistin methanesulfonate (CMS) associated nephrotoxicity are important. Our study attempts look into the prevalence of CMS-associated nephrotoxicity in Intensive Care Units (ICUs), and related risk factors. Materials and Methods: The study was conducted between September 2010 and April 2012 on 55 patients who underwent CMS treatment. Nephrotoxicity risk was defined based on the Risk Injury Failure Loss End-stage kidney disease criteria. Results: Fifty-five patients included in the study. A total of 22 (40%) patients developed nephrotoxicity. The correlation was detected between nephrotoxicity and patients over 65 with a high Acute Physiologic Assessment and Chronic Health Evaluation (APACHE) II score. APACHE II score was revealed an independent risk factor for nephrotoxicity. Conclusion: Advanced age and a high APACHE II score are significant risk factors in the development of nephrotoxicity at ICUs following CMS use. Patient selection and close monitoring are critical when starting CMS treatment.