Oxygen radicals and nitric oxide in rat mesenteric ischaemia-reperfusion: Modulation by L-arginine and N-G-nitro-L-arginine methyl ester

HAKLAR, GONCAGÜL; Ulukaya-Durakbasa, C; YÜKSEL, MERAL; DAĞLI, EMRULLAH; YALÇIN, AHMET

doi:10.1111/j.1440-1681.1998.tb02342.x

Oxygen radicals and nitric oxide in rat mesenteric ischaemia-reperfusion: Modulation by L-arginine and N-G-nitro-L-arginine methyl ester

HAKLAR G., Ulukaya-Durakbasa C., YÜKSEL M., DAĞLI E. T., YALÇIN A. S.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, cilt.25, sa.11, ss.908-912, 1998 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 25 Sayı: 11
Basım Tarihi: 1998
Doi Numarası: 10.1111/j.1440-1681.1998.tb02342.x
Dergi Adı: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.908-912
Anahtar Kelimeler: chemiluminescence, mesenteric ischaemia/reperfusion, nitric oxide, reactive oxygen species, superoxide radical, thiobarbituric acid-reactive substances, SUPEROXIDE, INJURY, PEROXYNITRITE
Marmara Üniversitesi Adresli: Evet

Özet

1. The aims of the present study were to detect changes in superoxide anion (O-2(.-)), nitric oxide (NO) and other reactive oxygen species (ROS) directly by measurement of chemiluminescence (CL) and to investigate the role of L-arginine, a nitric oxide synthase (NOS) substrate, and N-G-nitro-L-arginine methyl ester (L-NAME), a NOS inhibitor, together with their molecular enantiomers D-arginine and D-NAME, in a rat mesenteric ischaemia-reperfusion (I/R) model.