The determination of the stability constants of mixed Li- gand comlexes of creatinine-l-cysteine and creatinine-l- cysteine hydrochloride with Co(Ii), Cd(Ii), Zn(Ii), Mn(Ii): Using potentiometric method L-Sistein - Kreatinin'in ve L-sistein.HCl (BDHL-sistein) - Kreatinin'in Co(II), Cd(II), Zn(II), Mn(II) ile Kari{dotless}şi{dotless}k komplekslerinin kararli{dotless}li{dotless}k sabitlerinin potansi-yometrik yöntemle tayini

KARADERİ S., BİLĞİÇ ALKAYA D., Kurt Cücü A.

Turkish Journal of Pharmaceutical Sciences, cilt.11, sa.1, ss.33-43, 2014 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 1
  • Basım Tarihi: 2014
  • Dergi Adı: Turkish Journal of Pharmaceutical Sciences
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.33-43
  • Anahtar Kelimeler: BDHL-cysteine, Cadmium(II) and Manganez(II) complexes, Cobalt(II), Creatinine, L-cysteine, Mixed complex, Stability constants, Zinc(II)
  • Marmara Üniversitesi Adresli: Evet

Özet

In this study, a potentiometric titration technique has been used to determine stability constants for the various complexes of Zn(II), Co(II), Cd(II) and Mn(II) with creatinine and two amino acids. Stability constants of ternary systems have been evaluated by the method suggested by Irving-Rossotti at 25°C and 0.11M ionic strength (kept constant with NaC104) in aqueous solution. In addition, the conditional constants were calculated as a function of pH. The maximum values of the conditional formation constants were found to be in accordance with the mixed-ligand complex formation constants in a given pH region. In addition, the mole fractions of different species from mixed complexes were calculated by means of formation constants. The values of stability constants of mixed-ligand complexes at 25°C were calculated as follows: logK=3.20 forZn(II)-L-cysteine-creatinine,logK1=4.24 and logK2=3.58 for Co(II)-L-cysteine-creatinine2, logK=3.22 for Cd(II) - L-cysteine - creatinine, logK=3.65 forMn(II) - L-cysteine - creatinine and logK=5.34 for Co(II)-BDHL-cysteine-creatinine. logK=5.30 for Cd(II)-BDHL-cysteine-creatinine, logK=5.35 and logK2=3.93 for Zn(II) - BDHL-cysteine - creatinine2, logK1=5.40 and logK2=3.49 for Mn(II) - BDHL-cysteine - creatinine2.