Akademik Veri Yönetim Sistemi
Applications of Chemistry in Nanosciences and Biomaterials Engineering NanoBioMat 2025 – Winter Edition, Bucuresti, Romanya, 26 - 28 Kasım 2025, ss.84-85, (Özet Bildiri)
Osteoarthritis (OA) is a significant health problem among middle-aged and elderly populations due to its high prevalence and significant impact on daily living activities. Pathological changes initially occur in the articular cartilage of weight-bearing joints such as the knee, hip, and spine. In addition to cartilage degeneration, metabolic and structural changes also affect the subchondral bone and synovial membrane as the disease progresses. As glycosaminoglycans, glucosamine and chondroitin sulfate are classified as Symptomatic SlowActing Drugs for Osteoarthritis and are considered potential Disease-Modifying Osteoarthritis Drugs, as evidenced by the reduction in joint space narrowing in clinical trials.Both compounds are endogenously synthesized in the human body and serve as essential structural components of cartilage. They are reported to provide not only symptomatic relief but also have potential disease-modifying effects. As glycosaminoglycans, glucosamine and chondroitin sulfate are classified as Symptomatic Slow-Acting Drugs for Osteoarthritis and are considered potential Disease-Modifying Osteoarthritis Drugs, as evidenced by the reduction in joint space narrowing in clinical trials(1). Hydroxyapatite (HAp), are bioactive bioceramics that belong to the family of calcium phosphates and conform to the ideal formula of Ca 10(PO4)6(OH)2. Since the presence of hydroxyapatite and the produced bioactivity activate osteoblast adhesion, proliferation, and osteoblast activity, promoting the activity of bone tissue-forming cells is a property of great interest (2,3) In this study, glucosamine-chondroitin sulfate-doped hydroxyapatite (HAp) was successfully synthesized via wet precipitation to enhance the bioavailability of these poorly absorbed active ingredients. Subsequently, polymer composite coatings were produced that mimicked the composition and structure of natural bone tissue while providing improved coating stability. Structural characterization of the HAp/PVA/GL, HAp/PVA/CH, and HAp/PVA/GL/CH composites was performed using Fourier Transform Infrared Spectroscopy (FTIR) and X-ray Diffraction (XRD). The results confirmed that the synthesized composites were carbonate-modified hydroxyapatite. Consequently, by mimicking the structure and function of native bone tissue, they could lead to better treatment outcomes for articular cartilage defects, proving to be an effective treatment opportunity.