Turkish case of ethylmalonic encephalopathy misdiagnosed as short chain acyl-CoA dehydrogenase deficiency

BULUT F. D., Kör D., Şeker-Yılmaz B., Gül-Mert G., Kılavuz S., Önenli-Mungan N.

Metabolic Brain Disease, cilt.33, sa.3, ss.977-979, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1007/s11011-017-0152-8
  • Dergi Adı: Metabolic Brain Disease
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.977-979
  • Anahtar Kelimeler: Acrocyanosis, C4 and C5 acylcarnitines, Ethylmalonic encephalopathy, Short chain acyl-CoA dehydrogenase deficiency
  • Marmara Üniversitesi Adresli: Hayır

Özet

Ethylmalonic encephalopathy is a very rare autosomal recessively inherited inborn error of metabolism; characterized by encephalopathy, recurrent petechiae without bleeding diathesis, chronic diarrhea, and orthostatic acrocyanosis. Here, we describe a case of ethylmalonic encephalopathy with late onset neurologic symptoms and a confusing family history of two deceased brothers with the wrong suspicion of short chain acyl-CoA dehydrogenase deficiency.