The Role of EGFR, Hepatocyte Growth Factor Receptor (c-Met), c-ErbB2 (HER2-neu) and Clinicopathological Parameters in the Pathogenesis and Prognosis of Chordoma


Tosuner Z., Bozkurt S. U. , KILIÇ T., Yilmaz B.

TURKISH JOURNAL OF PATHOLOGY, cilt.33, sa.2, ss.112-120, 2017 (ESCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 33 Konu: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.5146/tjpath.2016.01378
  • Dergi Adı: TURKISH JOURNAL OF PATHOLOGY
  • Sayfa Sayıları: ss.112-120

Özet

Objective: Chordoma is a rare malignant bone tumor with a poor outcome. Although radiotherapy and gamma knife surgery have been used for treatment, providing a cure for the tumor is not easy, because of the frequent recurrences. Molecular targeted therapy against tyrosine kinases has been effective in the treatment of malignancies such as breast and lung cancers and brain tumors. We aimed to analyse the histopathological features of chordomas and the immunoexpression profiles of the three receptor tyrosine kinases of EGFR, c-Met and c-Erb-B2 in chordomas. We have correlated these results with recurrence and overall survival status of the patients.