The Role of EGFR, Hepatocyte Growth Factor Receptor (c-Met), c-ErbB2 (HER2-neu) and Clinicopathological Parameters in the Pathogenesis and Prognosis of Chordoma

Tosuner Z., Bozkurt S. U., KILIÇ T., Yilmaz B.

TURKISH JOURNAL OF PATHOLOGY, cilt.33, sa.2, ss.112-120, 2017 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.5146/tjpath.2016.01378
  • Dergi Adı: TURKISH JOURNAL OF PATHOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.112-120
  • Anahtar Kelimeler: Chordoma, EGFR, c-Met, c-Erb B2, SKULL-BASE CHORDOMAS, SACROCOCCYGEAL CHORDOMA, SINGLE INSTITUTION, BREAST-CANCER, MOBILE SPINE, PDGFR-ALPHA, EXPRESSION, TUMOR, PROLIFERATION, MECHANISMS
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective: Chordoma is a rare malignant bone tumor with a poor outcome. Although radiotherapy and gamma knife surgery have been used for treatment, providing a cure for the tumor is not easy, because of the frequent recurrences. Molecular targeted therapy against tyrosine kinases has been effective in the treatment of malignancies such as breast and lung cancers and brain tumors. We aimed to analyse the histopathological features of chordomas and the immunoexpression profiles of the three receptor tyrosine kinases of EGFR, c-Met and c-Erb-B2 in chordomas. We have correlated these results with recurrence and overall survival status of the patients.