Tadalafil Preserves Penile Nitric Oxide Synthase from Detrimental Effect of Paroxetine in Rats


Gul A., Pastuszak A., KABASAKAL L. , Bates J., Altinay S., Celik D. S. , ...More

EURASIAN JOURNAL OF MEDICINE, vol.51, no.1, pp.60-63, 2019 (Journal Indexed in ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.5152/eurasianjmed.2018.18160
  • Title of Journal : EURASIAN JOURNAL OF MEDICINE
  • Page Numbers: pp.60-63

Abstract

Objective: Paroxetine is a commonly prescribed SSRI that can impair erectile function in animal models via inhibition of nitric oxide synthase (NOS). Tadalafil potentiates nitric oxide (NO)-mediated responses in isolated trabecular smooth muscle and penile erection. The purpose of this study was to evaluate the impact of co-administering tadalafil with paroxetine on penile NOS levels in rats.