Tadalafil Preserves Penile Nitric Oxide Synthase from Detrimental Effect of Paroxetine in Rats


Gul A., Pastuszak A., KABASAKAL L. , Bates J., Altinay S., Celik D. S. , ...Daha Fazla

EURASIAN JOURNAL OF MEDICINE, cilt.51, sa.1, ss.60-63, 2019 (ESCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Konu: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.5152/eurasianjmed.2018.18160
  • Dergi Adı: EURASIAN JOURNAL OF MEDICINE
  • Sayfa Sayıları: ss.60-63

Özet

Objective: Paroxetine is a commonly prescribed SSRI that can impair erectile function in animal models via inhibition of nitric oxide synthase (NOS). Tadalafil potentiates nitric oxide (NO)-mediated responses in isolated trabecular smooth muscle and penile erection. The purpose of this study was to evaluate the impact of co-administering tadalafil with paroxetine on penile NOS levels in rats.