Epidermal growth factor receptor expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial

Bentzen S., Atasoy B. M., Daley F., Dische S., Richman P., Saunders M., ...Daha Fazla

JOURNAL OF CLINICAL ONCOLOGY, cilt.23, sa.24, ss.5560-5567, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 24
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1200/jco.2005.06.411
  • Dergi Adı: JOURNAL OF CLINICAL ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.5560-5567
  • Marmara Üniversitesi Adresli: Evet

Özet

Purpose Accelerated repopulation is a main reason for locoregional failure after fractionated radiotherapy for head and neck squamous cell carcinoma (HNSCC). Epidermal growth factor receptor (EGFR) is a key controller of cellular proliferation in HNSCC, which stimulated the current study to look for a direct link between EGFR status and a possible clinical advantage of accelerated radiotherapy.