Epidermal growth factor receptor expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial

Bentzen, SM; Atasoy, BESTE; Daley, FM; Dische, S; Richman, PI; Saunders, MI; Trott, KR; Wilson, GD

doi:10.1200/jco.2005.06.411

Epidermal growth factor receptor expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial

Bentzen S., Atasoy B. M., Daley F., Dische S., Richman P., Saunders M., ...Daha Fazla

JOURNAL OF CLINICAL ONCOLOGY, cilt.23, sa.24, ss.5560-5567, 2005 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 23 Sayı: 24
Basım Tarihi: 2005
Doi Numarası: 10.1200/jco.2005.06.411
Dergi Adı: JOURNAL OF CLINICAL ONCOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.5560-5567
Marmara Üniversitesi Adresli: Evet

Özet

Purpose Accelerated repopulation is a main reason for locoregional failure after fractionated radiotherapy for head and neck squamous cell carcinoma (HNSCC). Epidermal growth factor receptor (EGFR) is a key controller of cellular proliferation in HNSCC, which stimulated the current study to look for a direct link between EGFR status and a possible clinical advantage of accelerated radiotherapy.