Epidermal growth factor receptor expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial

Bentzen S., Atasoy B. M., Daley F., Dische S., Richman P., Saunders M., ...More

JOURNAL OF CLINICAL ONCOLOGY, vol.23, no.24, pp.5560-5567, 2005 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 24
  • Publication Date: 2005
  • Doi Number: 10.1200/jco.2005.06.411
  • Journal Name: JOURNAL OF CLINICAL ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.5560-5567
  • Marmara University Affiliated: Yes

Abstract

Purpose Accelerated repopulation is a main reason for locoregional failure after fractionated radiotherapy for head and neck squamous cell carcinoma (HNSCC). Epidermal growth factor receptor (EGFR) is a key controller of cellular proliferation in HNSCC, which stimulated the current study to look for a direct link between EGFR status and a possible clinical advantage of accelerated radiotherapy.