Effects of combined treatment of amiodarone and vitamin U on rat gingiva

Oktay S. , Turkyilmaz I. B. , Kaya S., Akyuz S. , Yanardag R., YARAT A.

INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, cilt.56, ss.759-763, 2018 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 56 Konu: 10
  • Basım Tarihi: 2018
  • Sayfa Sayıları: ss.759-763


Amiodarone a pharmaceutical used for the treatment of arrhythmias, causes many side effects. S-Methylmethionine sulfonium is a derivative of methionine and it is widely referred to as vitamin U (Vit U). In the peer-reviewed literature there is no study reported which focuses on the protective effects of Vit U against amiodarone's side effects on gingiva. In this study, we aimed to investigate the oxidative and inflammatory effect of amiodarone or putative protective role of Vit U on gingiva tissue. Rats were randomly divided into four groups as follows: control group: rats received corn oil; control+Vit U treated group (50 mg/kg/day); amiodarone group (100 mg/kg/day) and amiodarone+Vit U treated group (in same dose). Amiodarone and Vit U were given orally for 7 days. Vit U was given 1 h prior to the administration of amiodarone. Gingival tissues were taken from animals and homogenized in 0.9% NaCl. Lipid peroxidation and sialic acid levels were increased significantly, glutathione levels and superoxide dismutase activities were decreased significantly in the amiodarone group when compared with the control groups. Vit U combination with amiodarone reversed these effects. These results demonstrate that administration of Vit U may have protective effects on gingiva in amiodarone treatment by decreasing oxidative stress.