3D-printed polylactic acid (PLA)/polymethyl silsesquioxane (PMSQ)-based scaffolds coated with vitamin E microparticles for the application of wound healing

Anjrini N., Karabulut H., Ulağ S., Ege H., Noberi C., Dogan E., ...More

Emergent Materials, vol.1, pp.1-10, 2024 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 1
  • Publication Date: 2024
  • Doi Number: 10.1007/s42247-024-00711-3
  • Journal Name: Emergent Materials
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Page Numbers: pp.1-10
  • Marmara University Affiliated: Yes

Abstract

Skin is part of the integumentary and excretory system, which helps protect the body against infections. The skin should be properly treated when it gets injured, which requires a long healing process. In this study, 15% (w/v) polylactic acid (PLA) and 1 and 2% (w/v) polymethylsilsesquioxane (PMSQ) scafolds were fabricated using 3D printing technology, and the surfaces of each scafold were coated with 5% ethylcellulose (EC)/vitamin E microparticles using the electrospray method. The morphologies of the scafolds were characterized using a scanning electron microscope (SEM), and results showed that the pore sizes of the scafolds ranged from 136 to 265 μm. The vitamin E was completely released from the scafolds within 5 h. MTT test was performed with fbroblast cells and results proved the biocompatibility of the scafolds. These fndings showed that the scafolds may have good potential as a wound dressing material. The biodegradation test was performed in in vitro conditions and results showed that the surface coating with 5% EC/vitamin E microparticles on the 15% PLA/2% PMSQ scafolds increased the degradation rate of the scafolds.