Investigation of Th17 cell differentiation in immunodeficiencies associated with high IgE levels and/or autoimmunity

AKKOÇ T., Tevetoglu A., Ogulur I., Izgi A., AYDINER E., BARIŞ S., ...More

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, vol.1, no.2, pp.96-102, 2011 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 1 Issue: 2
  • Publication Date: 2011
  • Journal Name: CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Page Numbers: pp.96-102
  • Keywords: HIES, CVID, immunodeficiency, Th17
  • Marmara University Affiliated: Yes

Abstract

Objective: Hyper IgE Syndrome (HIES) and Common Variably Immunodeficiency (CVID) are immuno-deficiency diseases. HIES is characterized by recurrent skin abscesses, pneumonia, mucocutaneous fungal infections, eczama, eosinophilia and high serum IgE levels. CVID is characterized by recurrent bacterial infections in airways and gastrointestinal tract. In this study, differentiation of Th17 cells were aimed to be investigated in CVID and HIES patients.