Effects of Propofol and Midazolam on the Inflammation of Lungs after Intravenous Endotoxin Administration in Rats

Celik M. G., SARAÇOĞLU A., Saracoglu T., KÜRŞAD H., DOSTBİL A., AKSOY M., ...Daha Fazla

EURASIAN JOURNAL OF MEDICINE, cilt.47, sa.2, ss.109-114, 2015 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5152/eajm.2014.70
  • Dergi Adı: EURASIAN JOURNAL OF MEDICINE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.109-114
  • Anahtar Kelimeler: Sepsis, lung, neutrophil, propofol, midazolam, rat, RESPIRATORY-DISTRESS-SYNDROME, IN-VITRO, ANESTHETIC AGENTS, INTERLEUKIN-8, PHAGOCYTOSIS, NEUTROPHILS, THIOPENTONE, SURGERY, INJURY, SEPSIS
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective: Pulmonary complications are important sepsis (such as ARDS, diffuse pneumonia). Acute respiratory distress syndrome (ARDS) is characterized by the extensive migration of neutrophils into alveoli of the lungs. Propofol and midazolam are the most widely used agents for sedation in intensive care units. Aimed to investigate the effects of anaesthesia with propofol and midazolam on measured hemodynamic variables and neutrophil migration induced by Escherichia Coli endotoxin (ECE) in pulmonary viscera.