Neural correlates of speech anticipatory anxiety in generalized social phobia


Lorberbaum J., KÖSE A., Johnson M., Arana G., Sullivan L., Hamner M., ...Daha Fazla

NEUROREPORT, cilt.15, sa.18, ss.2701-2705, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 18
  • Basım Tarihi: 2004
  • Dergi Adı: NEUROREPORT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2701-2705
  • Anahtar Kelimeler: anticipatory anxiety, anxiety, fear, fMRI, functional magnetic resonance imaging, public speaking, social anxiety, social anxiety disorder, social phobia, CEREBRAL-BLOOD-FLOW, MEDIAL PREFRONTAL CORTEX, AMYGDALA ACTIVATION, PUBLIC SPEAKING, HUMANS, PAIN, FACES, PET
  • Marmara Üniversitesi Adresli: Hayır

Özet

Patients with generalized social phobia fear embarrassment in most social situations. Little is known about its functional neuroanatomy. We studied BOLD-fMRI brain activity while generalized social phobics and healthy controls anticipated making public speeches. With anticipation minus rest, 8 phobics compared to 6 controls showed greater subcortical, limbic, and lateral paralimbic activity (pons, striatum, amygdala/uncus/anterior parahippocampus, insula, temporal pole) - regions important in automatic emotional processing - and less cortical activity (dorsal anterior cingulate/prefrontal cortex) -regions important in cognitive processing. Phobics may become so anxious, they cannot think clearly or vice versa.