CELLULOSE CHEMISTRY AND TECHNOLOGY, cilt.56, ss.795-805, 2022 (SCI-Expanded)
In this study, magnetic Fe3O4
nanoparticles were synthesized and the magnetic surfaces of the nanoparticles were
modified with thiol groups. The chitosan polymer was modified with allyl groups and then bound to magnetic
nanoparticles by the thiol-en click reaction. The drugs paclitaxel (PTX) and doxorubicin (DOX) were loaded separately
and together into this prepared hybrid material, and then drug releases from the hybrid material were studied. The aim
of this paper is to present the results on the controlled release of DOX and PPT cancer drugs from chitosan-Fe3O4
nanoparticles at two different pH values (5.0 and 7.4). PTX was effectively loaded into chitosan-Fe3O4 nanoparticles
and slowly released up to 72.66% at pH 5 and 41.45% at pH 7.4 after 48 hours. DOX was effectively loaded into
chitosan-Fe3O4 nanoparticles and slowly released up to 30.5% at pH 5 and 23.3% at pH 7.4 after 48 hours.