H3K4 acetylation, H3K9 acetylation and H3K27 methylation in breast tumor molecular subtypes

Judes G., Dagdemir A., Karsli-Ceppioglu S. , Lebert A., Echegut M., Ngollo M., ...Daha Fazla

Epigenomics, cilt.8, ss.909-924, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 8 Konu: 7
  • Basım Tarihi: 2016
  • Doi Numarası: 10.2217/epi-2016-0015
  • Dergi Adı: Epigenomics
  • Sayfa Sayıları: ss.909-924


Aim: Here, we investigated how the St Gallen breast molecular subtypes displayed distinct histone H3 profiles. Patients & methods: 192 breast tumors divided into five St Gallen molecular subtypes (luminal A, luminal B HER2-, luminal B HER2+, HER2+ and basal-like) were evaluated for their histone H3 modifications on gene promoters. Results: ANOVA analysis allowed to identify specific H3 signatures according to three groups of genes: hormonal receptor genes (ERS1, ERS2, PGR), genes modifying histones (EZH2, P300, SRC3) and tumor suppressor gene (BRCA1). A similar profile inside high-risk cancers (luminal B [HER2+], HER2+ and basal-like) compared with low-risk cancers including luminal A and luminal B (HER2-) were demonstrated. Conclusion: The H3 modifications might contribute to clarify the differences between breast cancer subtypes.