Effect of Antibiotics on Polymorphonuclear Leukocyte Functions and Myeloperoxidase Activity, Glutathione and Malondialdehyde Levels in Allergic Asthma

RAYAMAN P., RAYAMAN E., Cevikbas A., Demirtunc R., Sehirli A. O., Alagoz S. G., ...Daha Fazla

POLISH JOURNAL OF MICROBIOLOGY, cilt.64, sa.1, ss.69-72, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 64 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.33073/pjm-2015-010
  • Dergi Adı: POLISH JOURNAL OF MICROBIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.69-72
  • Anahtar Kelimeler: allergic asthma, antibiotics, intracellular killing activity, myeloperoxidase, phagocytosis, IMMUNOTHERAPY, RHINITIS
  • Marmara Üniversitesi Adresli: Evet

Özet

We investigated the effect of ciprofloxacin, rifampicine and doxycydine on myeloperoxidase (MPO) activity, glutathione (GSH) and malondialdehyde (MDA) levels in allergic asthma patients and healthy volunteers. Polymorphonudear leukocytes(PMNs) were isolated with ficoll-hypaque gradient centrifugation method. MPO activity was assayed with modified o-dianisidine, GSH by Ellman's and MDA levels by Beuge's method. PMN functions and MDA levels of patients significantly decreased when compared with healthy volunteers. Ciprofloxacin significantly increased PMN functions, MPO activity and MDA levels of both groups. We have demonstrated that ciprofloxacin has beneficial effects on MPO activity and PMN functions in allergic asthma patients and healthy volunteers.