Sodium Alginate Microneedle Arrays Mediate the Transdermal Delivery of Bovine Serum Albumin

Demir Y. K. , Akan Z., KERİMOĞLU O.

PLOS ONE, cilt.8, sa.5, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Konu: 5
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1371/journal.pone.0063819
  • Dergi Adı: PLOS ONE


Background: The "poke and release" strategy for the delivery of macromolecules using polymeric microneedle (MN) is of great importance because it eliminates microneedle reuse, the risks of biohazardous sharps and cross contamination, and it requires no special disposal mechanism. The main objective of this study was the determination of the stability and delivery of bovine serum albumin (BSA) that was transported across human skin via sodium alginate (SA) microneedle arrays (MNs) and SA needle free patches using two different analytical methods.